Dr. Evanka Madan

Dr. Evanka Madan

Dr. Evanka Madan is a distinguished Consultant and Assistant Professor at Sir Ganga Ram Hospital, New Delhi, India. She holds a Ph.D. in Cancer Biochemistry from AIIMS, New Delhi, and an M.Sc. from PGIMER, Chandigarh.

With over nine years of postdoctoral research experience, Dr. Madan has worked at leading institutions such as the National Institute of Immunology (NII), Institute of Genomics and Integrative Biology (IGIB), and Jawaharlal Nehru University (JNU). Her expertise spans Cancer Biology, Cardiometabolic Disorders, and Host-Pathogen Interactions, particularly focusing on drug discovery for cancer and parasitic diseases like Leishmania, Tuberculosis. Dr. Madan’s research has led to substantial contributions in these fields, with international collaborations, including a research stint at the Albert Einstein College of Medicine in New York.

Her scientific work has been published in renowned journals such as Oncogene, International Journal of Cancer, ACS Infectious Diseases, Frontiers in Cellular and Infection Microbiology, iScience, Spectrum, JBSD, and IJMR. Additionally, she holds a patent for “A pharmaceutical composition targeting Leishmania-specific sphingosine kinase-1”, which highlights her commitment to advancing biomedical research and therapy.

Dr. Madan has been recognized with multiple prestigious awards, including the Scientist Pool Officer from CSIR, Young Scientist Fellowship from ICMR-DHR (2021-24), the Best Young Researcher Award at the 4th Science Conclave cum NBRCOM (2023, Alwar, India) and the Best Researcher Award in Cancer Biology under the International Young Scientists Award category (August 2024). She has received accolades for her oral and poster presentations at major national and international conferences across the US, Europe, Australia, UAE, and India.

In addition to her accolades, Dr. Madan has been invited to share her expertise at multiple esteemed forums. She delivered a Public Lecture on “Traditional Parasitic Plant Extracts Can Combat Drug-Resistant Malaria,” which is available on YouTube, and gave a scientific talk at the Third Biannual Meet of Delhi-NCR Basic Neuro-Oncology Group at AIIMS, New Delhi. Dr. Madan has also been invited as Chairperson for the Oncobiology track at the ISMPO-CON Conference (IHC, 2024) and as a speaker at several esteemed forums, including the IEC-VL Conference at Jamia Hamdard, MCCM Conference at the University of Kerala, and the NBRCOM Felicitation Ceremony (2024).

Her involvement in research grants has been pivotal. She had been involved in numerous research grants as an Independent Scientist at JNU. Dr. Madan’s research group at SGRH is at the forefront of Drug Discovery and studying the pathogenesis of infectious diseases, including Leishmania, Tuberculosis, and cardiometabolic disorders. Her work has greatly contributed to clinical research and the MAHE-PhD coursework, earning recognition within the academic and medical communities.

Dr. Madan is a recognized member of several professional bodies, including SYBS India (Life Member), PSI (Proteomics Society), European Society of Cardiology, and the International Society for Heart Research (ISHR). She is also an Editorial Board Member for the upcoming International Conferences on Young Scientists.

Her contributions to medical science and patient care have significantly enhanced the academic standing and research capabilities of her institution.

Patent

A pharmaceutical composition targeting Leishmania-specific sphingosine kinase and a method of preparation thereof. Inventors; Indian Patent application no. 202511003733 dated 16/01/2025

Publications

• Madan E*, Ganguly NK, Puri M, Pawar H, Selvapandiyan A, Muthuswami R, Zilberstein D, Madhubala R*. “Leishmania parasite arginine deprivation response pathway influences the host macrophage lysosomal arginine sensing machinery” The European Society Of Medicine. Medical Research Archives, 2024; 12 (10): 1-13. doi.org/10.18103/mra.v12i10.5800
• Ezenyi I#, Madan E#, Singhal J, Jain R, Chakrabarti A, Ghousepeer GD, Pandey, Ngozichukwuka Igoli, John Igoli, Shailja Singh. “Screening of traditional medicinal plant extracts and compound identifies a potent antileishmanial diarylheptanoid from Siphonochilus aethiopicus”. Published in J Biomol Struct Dyn, 2024;42(5):2449-2463. doi: 10.1080/07391102.2023.2212779. #Contributted equally
• Madan E*, Jain V, Ganguly NK, Singh VP. “Induction of hypoxic response despite normoxic conditions leads to vascular mitochondrial dysfunction in diet induced metabolic syndrome”. Under Revision in BBRC; 2024 (BBRC-24-7775)
• Shital S, Madan E, Selvapandiyan A, Ganguly NK. “An update on recombinant vaccines against leishmaniasis". Published in Indian J Med Res, 2024;160(3&4):323-337. doi: 10.25259/IJMR_1040_2024
• Singhal J, Madan E, Chaurasiya A, Srivastava P, Singh N, Kaushik S, Kahlon AK, Maurya MK, Marothia M, Joshi P, Ranganathan A and Singh S. “Host SUMOylation pathway negatively regulates protective immune responses and promotes Leishmania donovani survival”. Published in Front Cell Infect Microbiol, 2022; 6:12:878136. doi: 10.3389/fcimb.2022.878136
• Srivastava P#, Bansal R1#, Madan E, Shoaib R, Singhal J, Khlon AK, Gupta A, Garg S, Upadhyay P, Pati S, Ranganathan A, Singh S. “Identification of de novo peptide against palmitoyl acyltransferase 6 to block survivability and infectivity of Leishmania donovani aethiopicus”. Published in ACS Infect Dis, 2024; 14;10(6):2074-2088. doi: 10.1021/acsinfecdis.4c00063. #Contributted equally
• Behl A#, Shoaib R#, Leon FD, Kumari G#, Saini M#, Madan E#, Kumar V, Singh H, Kumari J, Maurya P, Garg S, Mishra PC, Arenz C, Singh S. “Human malaria parasite cold shock protein plays an essential role in asexual and sexual stage development and presents a druggable target”. Published in iScience, 2024; 27, 109918. doi.org/10.1016/j.isci.2024.109918. #Contributted equally
• Brar H and Roy G, Kanojia A, Madan E, Madhubala R, Muthuswami R. “Chromatin-remodelling factor BRG1 is a negative modulator of L. donovani in IFNY stimulated and infected THP-1 cells” Published in Front. Cell. Infect. Microbiol Sec. Parasite and Host, 2022; 12. doi.org/10.3389/fcimb.2022.860058
• Ojha SB, Sah R, Madan E, Bansal R, Roy S, Singh S. “Methanol extract of Cuscuta reflexa Roxb. possess anti-malarial activity in vitro and in vivo”. Published in Curr Microbiol, 2023;80(5):189. doi: 10.1007/s00284-023-03289
• Puri M, Brar H, Madan E, Srinivasan R, Rawat K, Gorthi SS, Kumari G, Sah R, Ojha SB, Panigrahi S, Dhangadamajh G, Muthuswami R, Singh S and Madhubala R. “Rapid diagnosis of Plasmodium falciparum malaria using a point-ofcare loop-mediated isothermal amplification device”. Published in Front. Cell. Infect. Microbiol. Sec. Parasite and Host, 2022; 12. doi.org/10.3389/fcimb.2022.961832
• Singhal J#, Rawat N#, Bansal R#, Madan E#, Srivastava P, Ghousepeer GD, Pandey RP, Ranganathan A, Singh S. “Chemical degradation identified Human p38-MAPK as a host target to combat parasitic infections”. Communicated to ACS Infectious Diseases, 2024, doi.org/10.1101/2024.12.19.629355. #Contributted equally
• Puri M, Brar H, Mittal N, Madan E, Srinivasan R, Rawat K, Moulik S, Chatterjee M, Gorthi SS, Muthuswami R and Madhubala R. “Rapid diagnosis of Leishmania infection with a portable loop-mediated isothermal amplification device”. Published in J Biosci. 2021;46(4):92. doi: 10.1007/s12038-021-00211-0.
• Sah R, Anand S, Dar W, Jain R, Kumari G, Madan E, Saini M, Gupta A, Joshi N, Hada R, Gupta N, Pati S, and Singh S. “Host-Erythrocytic Sphingosine-1-phosphate regulates Plasmodium histone deacetylase activity and exhibits epigenetic control over cell death and differentiation”. Published in Microbiology Spectrum, 2023; 11 (2) e02766-22. doi.org/10.1128/spectrum.02766-22
• Garg S#, Gupta P#, Munjal A# *, Kumari G# *, Biswas S# *, Madan E, Saini M, Behl A, Srivastava A, Jain R, Kaur A, Maurya P, Singhal J, Mandal A, Pati S, Ramalingam S*, Ranganathan A* and Singh S*. “CRISPR/Cas9 mediated functional characterization of erythrocyte LC3-interacting region (LIR)-anchoring protein to develop host-targeted irresistible antimalarial”. Published in Cell Reports, 2023; (1-34). Under Revision in Communications Biology-Nature, 2023. #Contributted equally
• Madan E, Dikshit B, Gowda S, Srivastava C, Sarkar C, Chattopadhyay P, Sinha S, Chosdol K. “FAT1 is a novel upstream regulator of HIF1α and invasion of high grade glioma”. Published in International Journal of Cancer, 2016; 139, 2570–2582
• Dikshit B, Irshad K, Madan E, Aggarwal N, Sarkar C, Chandra PS, Gupta DK, Chattopadhyay P, Sinha S, Chosdol K. “FAT1 acts as an upstream regulator of oncogenic and inflammatory pathways, via PDCD4, in glioma cells”. Published in Oncogene, 2013; 32, 3798–3808
• Vijayan V, Siddique IA, Gupta S, Madan E, Raj N, Gupta S. “Osteocalcin Alters Aggregation Pattern of Abeta42 to Form Complexes (AO) that Aid in Amyloid Reduction in Mouse Models of Alzheimer Disease.” Communicated to Journal of Biochemical Pharmacology; December, 2024
• Dharavath S, Tomar P, Ramachandran V, Bhrigu G, Khan FM, Madan E, Muthuswami R, Gourinath S “Inhibitors of Serine Acetyltransferase Induce Lethality in Entamoeba histolytica and Leishmnia donovani”. Communicated to European Journal of Medicinal Chemistry; June, 2024 (Manuscript Number: EJMECH-D-24-01720)
• Pawar H, Madan E, Koren RN, Myler PJ, Madhubala R, Beverley SM and Zilberstein D. “A unique target of rapamycin kinase with a PDZ domain regulates the arginine sensing pathway in Leishmania”. Communicated to EMBO reports; December, 2024

Chapters in Books

• A chapter entitled ‘Brain Tumors and Inflammation’ in a book on “Inflammation: the Common Link in Brain Pathologies” Irshad K, Madan E, Chosdol K. Published in Springer; Aug, 2016, pp 253-280
• A chapter entitled “Nuclear Factors Linking Cancer and Inflammation” in a book on “Nuclear Signaling Pathways and Targeting Transcription in Cancer” Chosdol K, Bhagat M, Dikshit B, Madan E, Chattopadhyay P, Sinha S. Published in Cancer Drug Discovery and Development, 2014, pp 121-154

Abstracts Published in Conferen. Proceedings

• Madan E, Puri M, Dan Z, Madhubala R “Molecular characterization of arginine sensing response in unravelling host-athogen interactions in Leishmania”. Abstract submitted to ICGEB Workshop: Molecular Biology of Leishmania, Italy, 2018. Published in The FEBS Journal, 2018 Page-16
• Chopra EM, Singh VP, Agrawal A “Cardiovascular Disease in Metabolic Syndrome associated with metabolic induction of hypoxic response”. Abstract submitted to 16th World Cardiology Congress Conference, 2016. Published in J Clin Exp Cardiolog 2016, 7:12(Suppl) Page-33 ISSN:2155-9880
• Chopra EM, Singh VP, Agrawal A “Cardiovascular Disease in Metabolic Syndrome associated with metabolic induction of hypoxic response”. Abstract submitted to 12th International Conference of The Asian Clinical Oncology Society (ACOS), 2016. Published in Journal of Carcinogenesis, Vol 15, April, 2016
• Grunblatt E, Madan E, Roy S, Goswami S. “Investigating the role of the anti-apoptotic protein ARC in breast cancer cell DNA repair”. Abstract submitted to AACR Annual Meeting. Published in Cancer Research; October, 2014
• Srivastava C, Irshad K, Madan E, H S, Gupta Y, Malik N, Chattopadhyay P, Sarkar C, Gupta DK, Sinha S, Chosdol K. “FAT1 modulates the expression of molecular regulators of hypoxia and stemness in glioma” Abstract submitted to Conference of The Asian Clinical Oncology Society (IACR), 2016. Published in Journal of Carcinogenesis, Vol 15, April, 2016
• Madan E, Dikshit B, Aggarwal N, Chattopadhyay P, Sinha S, Chosdol K. “Expression of FAT1 and its influence on SWH (Salvador Warts Hippo) pathway in human glioma cell lines”. Abstract submitted to 31st Annual Convention of the Indian Association for Cancer Research (IACR), 2012. Published in Journal of Cancer Research and Therapeutics, Vol 8, Supplement 1, January, 2012

Languages Spoken:

Education: BSc - Sri Venkateshwara College, Delhi University, New Delhi, India (2008) | MSc - PGIMER Chandigarh, India (2010) | Ph.D - AIIMS, New Delhi, India (2015)