Dr. M.H. Yashavarddhan joined Sir Ganga Ram Hospital (SGRH) in June 2024 as a scientist in the Department of Biotechnology and Research. He completed his PhD in Biotechnology from DRDO-INMAS, focusing on DNA damage signaling in response to ionizing radiation. With over seven years of post-doctoral experience at DRDO, ICMR, and SGRH, his expertise spans proteomics, radiation biology, oncology, and virology. He has contributed to significant research, including patented animal models for burn studies and novel diagnostic methods for SARS-CoV-2. At SGRH, he oversees the Mass Spectrometry facility, specializing in proteomics, metabolomics, and LC-MS diagnostics, with a focus on gallbladder cancer and cholangiocarcinoma. His research aims to discover early biomarkers for these cancers and improve personalized treatment methods. Dr. Yashavarddhan has published over 30 papers and holds four patents, making notable contributions to biotechnology and medical research.
1. Rana, R., Devi, S.N., Bhardwaj, A.K., Yashavarddhan, M.H., Bohra, D. and Ganguly, N.K., 2025. Exosomes as nature's nano carriers: Promising drug delivery tools and targeted therapy for glioma. Biomedicine & Pharmacotherapy, 182, p.117754.
2. Shaw, P., Sharma, A.K., Kalonia, A., Kumar, R., Yashavarddhan, M.H., Surya, P., Singh, S. and Shukla, S.K., 2024. Zinc oxide and gum tragacanth based composite hydrogel heals partial thickness burn wound by attenuating pro-inflammatory genes and enhancing regenerating growth factors. International Journal of Biological Macromolecules, p.138679.
3. Sharma, S., Shamjetsabam, N.D., Chauhan, K., Yashavarddhan, M.H., Gautam, P., Prakash, P., Choudhary, P., Chhabra, S.S., Acharya, R., Kalra, S.K. and Gupta, A., 2024. Quantitative tissue analysis reveals AK2, COL1A1, and PLG protein signatures: targeted therapeutics for meningioma. International Journal of Surgery, 110(12), pp.7434-7446.
4. Kumar, R., Sharma, A.K., Kirti, Kalonia, A., Shaw, P., Yashvarddhan, M.H., Vibhuti, A. and Shukla, S.K., 2024. Understanding innate and adaptive responses during radiation combined burn injuries. International Reviews of Immunology, pp.1-14.
5. Kirti, Sharma, A.K., Yashavarddhan, M.H., Kumar, R., Shaw, P., Kalonia, A. and Shukla, S.K., 2024. Exosomes: A new perspective for radiation combined injury as biomarker and therapeutics. Tissue and Cell, p.102563.
6. Sharma, A.K., Kalonia, A., Kumar, R., Kirti, Shaw, P., Yashvarddhan, M.H., Vibhuti, A. and Shukla, S.K., 2024. Alleviation of radiation combined skin injury in rat model by topical application of ascorbate formulation. International Journal of Radiation Biology, 100(5), pp.689-708.
7. Chauhan, K., Yashavarddhan, M.H., Gogia, A., Ranjan, V., Parakh, U., Makhija, A., Nanavaty, V., Ganguly, N.K. and Rana, R., 2024. Unraveling the Genetic Landscape of Pulmonary Arterial Hypertension in Indian Patients: A Transcriptome Study. Respiratory Medicine, p.107716.
8. Kumar, N., Tandon, A., Rana, R., Rana, D.S., Bhalla, A.K., Gupta, A., Sachdeva, M.P., Huirem, R.S., Chauhan, K., Yashavarddhan, M.H. and Basnal, A., 2023. Donor-derived cell-free DNA as a non-invasive biomarker for graft rejection in kidney transplant recipients: a prospective study among the Indian population. Diagnostics, 13(23), p.3540.
9. Yashavarddhan, M.H., Bohra, D., Rana, R., Tuli, H.S., Ranjan, V., Rana, D.S. and Ganguly, N.K., 2023. Comprehensive Overview of 2022 Human Monkeypox Outbreak and Its Pathology, Prevention, and Treatment: A Strategy for Disease Control. Microbiological Research, p.127504.
10. Yashavarddhan, M.H., Roy Pradhan, S., Gupta, A., Kumar, P., Kumar, A., Arif, N., Agrawal, U., Kumar, R.S. and Singh, S., 2023. Insights from establishing a high throughput viral diagnostic laboratory for SARS-CoV-2 RT-PCR testing facility: challenges and experiences. Frontiers in Public Health, 11, p.1122715.
11. Rana, R., Huirem, R.S., Kant, R., Chauhan, K., Sharma, S., Yashavarddhan, M.H., Chhabra, S.S., Acharya, R., Kalra, S.K., Gupta, A. and Jain, S., 2022. Cytochrome C as a potential clinical marker for diagnosis and treatment of glioma. Frontiers in oncology, 12, p.960787.
12. Sharma, A.K., Shukla, S.K., Kalonia, A., Shaw, P., Khanna, K., Yashavarddhan, M.H., Gupta, R. and Bhatnagar, A., 2022. Evaluation of Decontamination Efficacy of Electrolytically Generated Hypochlorous Acid for the Vesicating Agent: A Multimodel Study. Current Pharmaceutical Biotechnology, 23(2), pp.287-299.
13. Ranjan, R., Kalita, B., Singh, A., Yashavarddhan, M.H., Prakash, H. and Gupta, M.L., 2021. Prophylactic administration of podophyllotoxin and rutin combination assists the revival of radiation-induced hematopoietic suppression in lethally irradiated mice. Biochemical and Biophysical Research Communications, 549, pp.214-220.
14. Shukla, S.K., Sharma, A.K., Bajaj, S. and Yashavarddhan, M.H., 2021. Radiation proteome: a clue to protection, carcinogenesis, and drug development. Drug Discovery Today, 26(2), pp.525-531.
15. Yashavarddhan, M.H., Sharma, A.K., Chaudhary, P., Bajaj, S., Singh, S. and Shukla, S.K., 2021. Development of hematopoietic syndrome mice model for localized radiation exposure. Scientific Reports, 11(1), p.89.
16. Shukla, S.K., Sharma, A.K., Shaw, P., Kalonia, A., Yashavarddhan, M.H. and Singh, S., 2020. Creation of rapid and reproducible burn in animal model with a newly developed burn device. Burns, 46(5), pp.1142-1149.
17. Sharma, A.K., Shukla, S.K., Kalonia, A., Shaw, P., Yashavarddhan, M.H. and Manda, K., 2020. Evaluation of wound healing potential of ascorbic acid, castor oil, and gum tragacanth formulation in murine excisional wound model. Pharmacognosy Magazine, 16(69).
18. Shukla, S.K., Sharma, A.K., Gupta, V. and Yashavarddhan, M.H., 2019. Pharmacological control of inflammation in wound healing. Journal of tissue viability, 28(4),pp.218-222.
Yashavarddhan, M.H., Shukla, S.K., and Sharma, A.K., Can γH2AX assay be an endpoint in drug discovery? Clinical Pharmacology Toxicology Research. December-2017;1(1):9-12. (I.F. 0.0).
19. Yashavarddhan, M.H., Shukla, S.K., Chaudhary, P., Srivastava, N.N., Joshi, J., Suar, M. and Gupta, M.L., 2017. Targeting DNA repair through podophyllotoxin and rutin formulation in hematopoietic radioprotection: An in silico, in vitro, and in vivo study. Frontiers in Pharmacology, 8, p.750.
20. Singh, A., Yashavarddhan, M.H., Kalita, B., Ranjan, R., Bajaj, S., Prakash, H. and Gupta, M.L., 2017. Podophyllotoxin and rutin modulates ionizing radiation-induced oxidative stress and apoptotic cell death in mice bone marrow and spleen. Frontiers in immunology, 8, p.183.
21. Bajaj, S., Singh, A., Kalita, B., Yashavarddhan, M.H., Ranjan, R., Farooqi, H. and Gupta, M.L., 2017. Gamma radiation Induced Intestinal Proteomic modulation in mice: a two Dimensional electrophoretic analysis. Defence Life Science Journal, 2(3), pp.327-334.
22. Yashavarddhan, M.H., Kumar, S., Kumar, A. and Suar, M., 2017. Response of normal cells following multiple radiation exposure under radiotherapy setting. Defence Life Science Journal, 2(3), pp.335-42.
23. Kalita, B., Ranjan, R., Singh, A., Yashavarddhan, M.H., Bajaj, S. and Gupta, M.L., 2016. A combination of podophyllotoxin and rutin attenuates radiation induced gastrointestinal injury by negatively regulating NF-κB/p53 signaling in lethally irradiated mice. PLoS One, 11(12), p.e0168525.
24. Yashavarddhan, M.H., Shukla, S.K., Srivastava, N.N., Suar, M., Dutta, S., Kalita, B., Ranjan, R., Singh, A., Bajaj, S. and Gupta, M.L., 2016. γH2AX formation kinetics in PBMCs of rabbits exposed to acute and fractionated radiation and attenuation of focus frequency through preadministration of a combination of podophyllotoxin and rutin hydrate. Environmental and Molecular Mutagenesis, 57(6), pp.455-468.
25. Dutta, S., Yashavarddhan, M.H., Srivastava, N.N., Ranjan, R., Bajaj, S., Kalita, B., Singh, A., Flora, S.J. and Gupta, M.L., 2016. Countering effects of a combination of podophyllotoxin, podophyllotoxin β-d-glucoside and rutin hydrate in minimizing radiation induced chromosomal damage, ROS and apoptosis in human blood lymphocytes. Food and Chemical Toxicology, 91, pp.141-150.
26. Srivastava, N.N., Shukla, S.K., Yashavarddhan, M.H., Devi, M., Tripathi, R.P. and Gupta, M.L., 2014. Modification of radiation‐induced DNA double strand break repair pathways by chemicals extracted from Podophyllum hexandrum: An in vitro study in human blood leukocytes. Environmental and molecular mutagenesis, 55(5), pp.436-448.
1. Bohra, D., Devi, S.N., Yashavarddhan, M.H. and Rana, R., 2025. Current epigenetics and advancement of exosomal biomarkers in biliary tract cancer. In Advances in Cancer Biomarkers Research (pp. 279-305). Academic Press, Elsevier.
2. Sharma, A.K., Shaw, P., Kalonia, A., Yashavarddhan, M.H., Chaudhary, P., Vibhuti, A. and Shukla, S.K., 2021. Recent perspectives in radiation-mediated DNA damage and repair: role of NHEJ and alternative pathways. DNA-Damages and Repair Mechanisms.
3. Yashavarddhan, M.H., Bajaj, S., Shukla, S.K. and Vibhuti, A., 2021. Biotransformation: Basics and Applied Perspectives. Environmental Microbiology and Biotechnology: Volume 2: Bioenergy and Environmental Health, pp.337-357.
4. Bajaj, S., Sharma, A.K., Yashavarddhan, M.H., Vibhuti, A., Shukla, S.K.,. 2019 Advancement in biomarkers discovery for elderly population, Chapter ID: 62821, Book ID:16084, Nova publishers.
1. Device for burn studies on animal model. Sandeep Kumar Shukla, Ajay Kumar Sharma, M H Yashavarddhan, Kailash Manda, Sukhvir Singh, Patent No 518823 Award date 04/03/2024. Indian Patent office, India. (Granted)
2. An aqueous wound healing composition. Sandeep Kumar Shukla, Ajay Kumar Sharma, M H Yashavarddhan, Kailash Manda, Patent Application No 201711033403 Application date 27/10/2020,Indian Patent office, India. Granted (Waiting for NBA Approval)
3. A Method For Preparation Of Sample For Nucleic Acid Extraction Free PCR, R. Suresh Kumar, M H Yashavarddhan, Ravi Shankar Yadav, A Babar Ali, Shalini Singh, Patent Application No 202211041619 Application date 26/01/2024, Indian Patent office, India. (Application published)
4. A burn wound healing composition and a method for preparation thereof, Sandeep Kumar Shukla, Ajay Kumar Sharma, Priyanka Shaw, Aman Kalonia, Rishab Kumar, Kirti and M H Yashavarddhan, Patent Application No 202411035307 Application date 24/05/2024, Indian Patent office, India. (Application filed)
