Dr. Evanka Madan is a distinguished Consultant and Associate Professor at Sir Ganga Ram Hospital, New Delhi, India. She holds a Ph.D. in Cancer Biochemistry from AIIMS, New Delhi, and an M.Sc. from PGIMER, Chandigarh.
With over ten years of postdoctoral research experience, Dr. Madan has worked at leading institutions such as the National Institute of Immunology (NII), Institute of Genomics and Integrative Biology (IGIB), and Jawaharlal Nehru University (JNU). Her expertise spans Cancer Biology, Cardiometabolic Disorders, and Host-Pathogen Interactions, with a dedicated focus on novel biomarker discovery and drug development for malignancies and infectious diseases like Leishmaniasis and Tuberculosis. Dr. Madan’s research has led to substantial contributions in these fields, with international collaborations, including a research stint at the Albert Einstein College of Medicine in New York.
Her scientific work has been published in renowned journals such as Oncogene, International Journal of Cancer, ACS Infectious Diseases, PLOS Neglected Tropical Diseases, Frontiers in Cellular and Infection Microbiology, iScience, Spectrum, JBSD, and IJMR. Additionally, she holds a Patent for “A Unique Drug Formulation Targeting Leishmania-specific Sphingosine Kinase-1 with Promising Antileishmanial Activity,” which highlights her commitment to advancing biomedical research and therapy.
Dr. Madan has been the recipient of several prestigious national and international awards in recognition of her outstanding contributions to biomedical research. Her notable accolades include the Scientist Pool Officer Fellowship from the Council of Scientific and Industrial Research (CSIR), the Young Scientist Fellowship from the Indian Council of Medical Research–Department of Health Research (ICMR-DHR), the Best Young Researcher Award at the 4th Science Conclave cum NBRCOM, and the Best Researcher Award in Cancer Biology under the International Young Scientists Award category (August 2024).
In 2026, she was honored with the Best Research Paper Award for her original research article during the Founder's Day Event organized by Sir Ganga Ram Hospital, New Delhi. In addition, Dr. Madan has received numerous awards and recognitions for her oral and poster presentations at several prestigious national and international scientific conferences held across the United States, Europe, Australia, the United Arab Emirates, and India, reflecting the global impact and excellence of her research contributions.
In addition to her academic distinctions, Dr. Evanka Madan has been invited to share her expertise at several prestigious national forums. She delivered a public lecture titled “Traditional Parasitic Plant Extracts Can Combat Drug-Resistant Malaria,” which is available on YouTube, and presented a scientific talk at the Third Biannual Meet of the Delhi-NCR Basic Neuro-Oncology Group at All India Institute of Medical Sciences, New Delhi.
She has served as Chairperson for the Oncobiology Track at the ISMPO-CON Conference (IHC, 2024). She has also been a Jury Member/Panelist for scientific sessions at National Institute of Malaria Research (2025), Hamdard Institute of Medical Sciences and Research (2026), AIMMSCR, Amity University (2026).
Dr. Madan has delivered invited talks at the NSGDCON Manekshaw Centre, Delhi Technological University, IEC-VL Conference at Jamia Hamdard, the Drug Discovery Conference at Jamia Millia Islamia, the CCTR Conference at Postgraduate Institute of Medical Education and Research, as well as at Delhi Pharmaceutical Sciences and Research University, Shaheed Rajguru College of Applied Sciences for Women, and Amity Institute of Virology and Immunology, including sessions on antimicrobial resistance and career orientation in biomedical sciences.
Her involvement in research grants has been pivotal. She had been involved in numerous research grants as an Independent Scientist at JNU. At Sir Ganga Ram Hospital, she has successfully secured extramural funding for the project “Preclinical Evaluation of the Adjunct Therapeutic Potential of Terminalia chebula against Multidrug-Resistant ESKAPE Pathogens” supported by Indian Council of Medical Research and the Ministry of AYUSH. She has also received funding from Defence Research and Development Organisation for the project titled “Role of Platelet-Derived Extracellular Vesicles (PDEVs) in Hypobaric Hypoxia–Induced Vascular Dysfunction.” In addition, she leads institutionally supported intramural projects, including “Profiling Inflammation & Acute Kidney Injury Biomarkers in Heart Failure & STEMI Patients” and “Synergistic Use of Biomarkers in Tuberculosis Detection,” reflecting her integrated focus on cardiovascular inflammation, critical care biomarkers, and infectious diseases.
Dr. Madan’s research group at SGRH is at the forefront of Novel Biomarker Discovery and Drug Development. She aims to understand biochemical and molecular mechanism(s) of metabolic disorder-induced chronic inflammatory diseases including cardiovascular complications and cancer through cutting edge research, and discover and develop potential mechanism-based molecular medicine for clinical intervention and therapy.
Her work has greatly contributed to the MAHE-PhD coursework and Clinical Research, earning recognition within the academic and medical communities. She currently mentors’ researchers, fostering their academic and professional growth while promoting interdisciplinary collaborations across institutions like ICGEB, JNU, Jamia Hamdard and DU.
At national level, she contributes as a Corresponding Editor for Elsevier book “Cardiometabolic Disorders: Biomarkers, Mitochondria, Microbiota and Other Emerging Areas” and a reviewer for Elsevier book “Immunity and Immunotherapy in Inflammatory Bowel Diseases (IBD): Mechanisms and Innovations” and the peer-reviewed journal including “Neoplasma”
Dr. Madan is a recognized member of several professional bodies, including SYBS India (Life Member), Proteomics Society, European Society of Cardiology, International Society for Heart Research, International Academy of Cardiovascular Sciences, Indian Society for Parasitology, Indian Association of Medical Microbiologists.
In addition, she serves as an Editorial Board Member for the International Conferences on Young Scientists. Dr. Madan is also a Board Member, Scientific Speaker, and Conference Planning Committee Member of the International Society for Adaptive Medicine and the Aging Heart, contributing to academic leadership and scientific program development in the field of adaptive medicine and cardiovascular aging.
Patent Filed:
● A pharmaceutical composition targeting Leishmania-specific sphingosine kinase and a method of preparation thereof. Inventors: Madan E, Singh S, Pati S, Bansal R; Indian Patent application no. 202511003733 dated 16/01/2025
Publications:
● Madan E, Bansal R, Singhal J, Saini M, Shafi S, Joshi N, Singh S. “Targeting Leishmania donovani Sphingosine Kinase 1 using PF-543 enhances immune response and limits parasite load.” PLOS Neglected Tropical Diseases 20(3): e0013102. March 2026, doi.org/10.1371/journal.pntd.0013102
● Jain K, Goel A, Mehra D, Rathore DK, Binayke A, Aggarwal S, Ganguly S, Awasthi A, Madan E*, Ganguly NK* “Cytokine profiling identifies circulating IL- 2, IL23 and sPD-L1 as prognostic biomarkers for treatment outcomes in Non-Small cell Lung Cancer patients undergoing anti-PD1 therapy” Published in Frontiers in Oncology, July, 2025; Volume 15 - 2025 | doi: 10.3389/fonc.2025.1628379
● Madan E*, Ganguly NK, Puri M, Pawar H, Selvapandiyan A, Muthuswami R, Zilberstein D, Madhubala R*. “Leishmania parasite arginine deprivation response pathway influences the host macrophage lysosomal arginine sensing machinery” The European Society Of Medicine. Medical Research Archives, 2024; 12 (10): 1-13. doi.org/10.18103/mra.v12i10.5800
● Madan E, Singhal J, Gupta A, Mukherjee S, Dar W, Jha N, Gupta P, Pati S, Ramalingam S, Singh S. “Crispr-Cas9 mediated identification of human macrophage SphK-1 as druggable target for development of anti-leishmanial chemotherapeutics”. Published on BioRxiv. doi: https://doi.org/10.1101/2025.08.18.670766. Under Revision Wiley Cell Biochemistry and Function, April, 2026
● Ezenyi I#, Madan E#, Singhal J, Jain R, Chakrabarti A, Ghousepeer GD, Pandey, Ngozichukwuka Igoli, John Igoli, Shailja Singh. “Screening of traditional medicinal plant extracts and compound identifies a potent antileishmanial diarylheptanoid from Siphonochilus aethiopicus”. Published in J Biomol Struct Dyn, 2024;42(5):2449-2463. doi: 10.1080/07391102.2023.2212779. #Contributted equally
● Madan E*, Jain V, Singh VP. “Induction of hypoxic response despite normoxic conditions leads to vascular mitochondrial dysfunction in diet induced metabolic syndrome”. Published in Dizen Dizhi Journal; May, 2025. doi.org/10.37896/Dizhen Dizhi 17.05/105202
● Shital S, Madan E, Selvapandiyan A, Ganguly NK. “An update on recombinant vaccines against leishmaniasis". Published in Indian J Med Res, 2024;160(3&4):323-337. doi: 10.25259/IJMR_1040_2024
● Singhal J, Madan E, Chaurasiya A, Srivastava P, Singh N, Kaushik S, Kahlon AK, Maurya MK, Marothia M, Joshi P, Ranganathan A and Singh S. “Host SUMOylation pathway negatively regulates protective immuneresponses and promotes Leishmania donovani survival”. Published in Front Cell Infect Microbiol, 2022; 6:12:878136. doi: 10.3389/fcimb.2022.878136
● Srivastava P#, Bansal R#, Madan E, Shoaib R, Singhal J, Khlon AK, Gupta A, Garg S, Upadhyay P, Pati S, Ranganathan A, Singh S. “Identification of de novo peptide against palmitoyl acyltransferase 6 to block survivability and infectivity of Leishmania donovani aethiopicus”. Published in ACS Infect Dis, 2024; 14;10(6):2074-2088. doi: 10.1021/acsinfecdis.4c00063. #Contributted equally
● Behl A#, Shoaib R#, Leon FD, Kumari G#, Saini M#, Madan E#, Kumar V, Singh H, Kumari J, Maurya P, Garg S, Mishra PC, Arenz C, Singh S. “Human malaria parasite cold shock protein plays an essential role in asexual and sexual stage development and presents a druggable target”. Published in iScience, 2024; 27, 109918. doi.org/10.1016/j.isci.2024.109918. #Contributted equally
● Brar H and Roy G, Kanojia A, Madan E, Madhubala R, Muthuswami R. “Chromatin-remodelling factor BRG1 is anegative modulator of L. donovani in IFNY stimulated and infected THP-1 cells” Published in Front. Cell. Infect. Microbiol Sec. Parasite and Host, 2022; 12. doi.org/10.3389/fcimb.2022.860058
● Ojha SB, Sah R, Madan E, Bansal R, Roy S, Singh S. “Methanol extract of Cuscuta reflexa Roxb. possess anti-malarial activity in vitro and in vivo”. Published in Curr Microbiol, 2023;80(5):189. doi: 10.1007/s00284-023-03289
● Puri M, Brar H, Madan E, Srinivasan R, Rawat K, Gorthi SS, Kumari G, Sah R, Ojha SB, Panigrahi S, Dhangadamajh G, Muthuswami R, Singh S and Madhubala R. “Rapid diagnosis of Plasmodium falciparum malaria using a point-ofcare loop-mediated isothermal amplification device”. Published in Front. Cell. Infect. Microbiol. Sec. Parasite and Host, 2022; 12. doi.org/10.3389/fcimb.2022.961832
● Puri M, Brar H, Mittal N, Madan E, Srinivasan R, Rawat K, Moulik S, Chatterjee M, Gorthi SS, Muthuswami R and Madhubala R. “Rapid diagnosis of Leishmania infection with a portable loop-mediated isothermal amplification device”. Publ in J Biosci. 2021;46(4):92. doi: 10.1007/s12038-021- 00211-0.
● Sah R, Anand S, Dar W, Jain R, Kumari G, Madan E, Saini M, Gupta A, Joshi N, Hada R, Gupta N, Pati S, and Singh S. “Host-Erythrocytic Sphingosine- 1-phosphate regulates Plasmodium histone deacetylase activity and exhibits epigenetic control over cell death and differentiation”. Published in Microbiology Spectrum, 2023; 11 (2) e02766-22. doi.org/10.1128/spectrum.02766-22
● Vijayan V, Siddique IA, Gupta S, Madan E, Raj N, Gupta S. “Osteocalcin Modulates Abeta42 Aggregation to Aid in Amyloid Reduction in Mouse Models of Alzheimer Disease.” Published in Experimental Neurology; May, 2025. doi: 10.1016/j.expneurol.2025.115322
● Singhal J, Rawat N, Bansal R, Gupta A, Srivastava P, Madan E, Jha N, Ghousepeer GD, Pandey RP, Ranganathan A, Singh S. “Chemical degradation of Human p38-MAPK reveals it as a potential host target to combat parasitic infections by Leishmania donovani and Plasmodium falciparum”. Published in Communications Biology, June 2026.
● Mukherjee S, Sharma A, Upadhyay P, Madan E, Pati S, Singh S. “Dynamic s-acylation of schizophrenia-linked antioxidants explicate the redox flexibility of human microglia during inflammation”. Under Communication in Glia Neurobiology Journal. doi: https://doi.org/10.64898/2026.04.28.721236
● Madan E, Dikshit B, Gowda S, Srivastava C, Sarkar C, Chattopadhyay P, Sinha S, Chosdol K. “FAT1 is a novel upstream regulator of HIF1α and invasion of high grade glioma”. Published in International Journal of Cancer, 2016; 139, 2570–2582
● Dikshit B, Irshad K, Madan E, Aggarwal N, Sarkar C, Chandra PS, Gupta DK, Chattopadhyay P, Sinha S, Chosdol K. “FAT1 acts as an upstream regulator of oncogenic and inflammatory pathways, via PDCD4, in glioma cells”. Published in Oncogene, 2013; 32, 3798–3808
● Dharavath S, Tomar P, Khan FM, Bhrigu G, Ramachandran V, Madan E, Muthuswami R, Gourinath S “Inhibitors of Serine Acetyltransferase Induce Lethality in Entamoeba histolytica and Leishmnia donovani”. Published in ACS Infect Dis; September, 2025.
● Ojha S, Sah R, Madan E, Keshari B, Dehury B; Singh S “Synergistic effect of methanol extract derived bioactive fractions of Cuscuta reflexa with artemisinin and in silico prediction of potential antimalarial compounds" Communicated to Journal of Pharmaceutical and Biomedical Analysis; December, 2025.
● Subham K, Jena S, Ojha M, Madan E, Singh S. “Corona from plant moieties enhances the anticancer property of green-synthesized zinc oxide nanoparticles”. Under Communication in Materials Chemistry and Physics; December, 2025.
● Munjal A, Purkayastha D, Rawat N, Parveen N, Leon F, Saini M, Madan E, Maurya M, Arenz C, Karmodiya K, Singh S. “Targeting a novel double-stranded DNA-binding protein of Plasmodium falciparum impairs parasite growth by repressing global gene expression. Communicated to Journal of Biological Chemistry, November, 2025
● A chapter entitled ‘Brain Tumors and Inflammation’ in a book on “Inflammation: the Common Link in Brain Pathologies” Irshad K, Madan E, Chosdol K. Published in Springer; Aug, 2016, pp 253-280
● A chapter entitled “Nuclear Factors Linking Cancer and Inflammation” in a book on “Nuclear Signaling Pathways and Targeting Transcription in Cancer”
Chosdol K, Bhagat M, Dikshit B, Madan E, Chattopadhyay P, Sinha S. Published in Cancer Drug Discovery and Development, 2014, pp 121-154
● A chapter entitled “Role of cytokines in Cancer Immunology” in an Elsevier book on “Immunity to Immunotherapy in Cancer, Mechanisms and Limitations”, Madan E*, Bissa B, Goel A, Chandra N, Jain K, Tiwari A, Soni N, Mandik D. Published. 2026, Pages 219-263
● A Chapter entitled “Role of Beta-Cells in Tumor Immunity” in an Elsevier book on “Immunity to Immunotherapy in Cancer”, Madan E*, Gulati P, Singh R, Chandra N, Patra S, Mandlik D. Published. June, 2026 Pages 103-127
