Research at SGRH

Sir Ganga Ram Hospital (SGRH) believes research to be an integral aspect of modern day medicine that allows the clinician to scientifically test assumptions, recognize uncertainties, widen perspective, resolve dilemmas and understanding divergent options and explore strategic questions. The existing facilities of teaching and research at SGRH together with a very large pool of patients makes for an ideal environment to evolve SGRH into an academic institution with a strong research base wherein the ultimate beneficiary is the patient.

A network of academically inclined clinicians of the Hospital and staff of the Clinical and Laboratory Facilities is available so that ideas generated in the clinics can be tested in a clinical research setting. Such a network will also help to develop discussion groups leading to generation of new ideas and discoveries in the laboratory, which can then be put to clinical testing in patients.

Department of Research, a Core Research Facility

Department of Research is a central facility with state-of-the-art equipments to support clinical research as well as promote translation research. The aim of the department is to promote laboratory-based investigation in multi-disciplinary areas, assist clinicians in pursuing their interest in research and provide technical and scientific manpower through collaborative projects. This is to facilitate ‘bench to bed’ side medicine and conduct innovative research to generate new knowledge in biology and medicine. Thus, as a central research department, it is responsible for bridging the various departments of the hospital to promote the highest level of scientific integrity, public accountability and social responsibility in the conduct of science.  In realizing these goals, the department provides leadership and direction to programs designed ultimately to improve the health-care system.

Toward this end, the ‘missionof the Department of Research is to foster fundamental creative discoveries and innovative research strategies, protect and improve human health and, at the same time, to promote the highest level of scientific integrity, accountability, and social responsibility in the conduct of biomedical research.

The academic staff and post-graduate students of the department, conducts a wide range of researches and studies, particularly in the fields of oncology, immunology and molecular & cell biology. In addition, the department manages clinical / non-clinical studied by supporting every phase of preclinical / clinical development, according to NABH / ISO standard. Here are mentioned a few of the departments (as depicted in the sketch below) that are actively involved in various research activities along with the Department of Research. Presently, our department has established protocols to carry-out various molecular biological associated researches

• Research Grants received from different funding agencies

Academics at Sir Ganga Ram Hospital

SGRH has been recognized by National Board of Examinations as a teaching hospital to impart teaching and training of Diplomate of National Board of Examinations for Broad / Super-specialty degrees and Post-doctoral Fellowships in sub-specialties. The Hospital has been accorded the status of an Approved Research Center to undertake Post-Graduate students who can pursue higher studies to obtain a PhD degree in medical science subjects (details are mentioned below) by Guru Gobind Singh Indraprastha University (GGSIPU)

We the Team.....

Left to Right : (Standing) Dr Vibha Taneja, Dr Anuja Krishnan, Dr Selvapandiyan, Dr. NK Ganguly, Dr Sangeeta Choudhury,Dr. Dheeraj Mohania,Dr. Veronique Dinand, Ms Parul Chug (Sitting) Mr Chitrak Gupta, Mr Pramod Sahoo, Mr Swaroop Singh

The Department is advised by Prof. N. K. Ganguly, assisted by the Assoc Prof and Consultant, Dr. Sangeeta Choudhury and other faculty members Drs. Veronique Dinand, Vibha Taneja, Dheeraj Mohania and our Honorary Scientists Dr Selvapandiyan. Other team members are Ms Kriti Jain (Junior Scientist), Ms Parul Chug (Statistician) and Mr Chitrak Gupta (Secretary to Chairman), Mr Pramod Sahoo (Jr. Executive Mr Radhyesh Notiyal (Assistant Manager). This team not only manages the functioning of the department but also provides invaluable support to Sir Ganga Ram Hospital in its research endeavors. Sir Ganga Ram Hospital is the only private hospital comprising of an independent state-of-art research facility.

The Department of Research in Sir Ganga Ram Hospital (SGRH) has a three part mission: teaching, research and supporting all scientific undertakings

The mission is to:

• Transliterate new facts in advancement of biomedical knowledge, that will lead to better health for all
• Train the next generation of scholars to excel in advancement of medical science
• Establish linkages across clinical departments to promote transfer of knowledge
• Establish linkages with national and international academic organizations to broaden contemporary knowledge
• Enhance association with bio-pharmaceutical companies to translate new evidence/knowledge for improving human health

The Department

The Department of Research since its establishment in 2007 with a maximum staff of six membersalong with 6-7 active researchers networking across the hospital, undertook the task of evolving as a dedicated facility with state-of-the-art equipments.  One of its major responsibilities is to bridge various departments to foster laboratory-based investigation in multi-disciplinary areas to support clinical research by developing intra-/inter-departmental collaborative research projects.

The academic faculty of the department is involved in clinical and basic research in different aspects of medicine. Mainly, research activity is conducted by a core research group (Department of Research) which pursues novel ideas at a fundamental level that have the potential to evolve into practical diagnostics or therapeutic practices. The infrastructure of the department is well established with this dedicated team of researchers who provides support to various departments to conduct their research activities. One of the main aims is to ultimately translate research findings into health care services and strategies, for use by clinicians and evaluate innovative studies to improve the effectiveness and efficiency in providing evidence-based practice.

• On-going Research Projects
• Extramural funded Projects

Intramural funded (Research Development Program)Projects (2016-2017):

Project Proposals submitted for external funding (2013)

1. Mapping of the Resource Requirements for Basic Science and Biomedical Research for Development of Drugs, Diagnostics, Vaccines, Implants and DevicesPrincipal Investigator: Prof. N. K. Ganguly (Department of Biotechnology)
2. Designing a unit of policy research based on definitive set of proposals spanning a broad spectrum of health technology issues.Principal Investigator – Prof. N.K. Ganguly (Department of biotechnology)
3. Mapping of DBT Funding in Neglected Tropical DiseasesPrincipal Investigator: Prof. N. K. Ganguly (Department of Biotechnology / Bill & Melinda Gates Foundation)
4. Understanding the pathogenesis of hereditary systemic amyloidosis using yeast as a model systemPrincipal Investigator: Dr. Vibha Taneja (Department of Biotechnology)
5. Functional Characterization of genes in LeishmaniaPrincipal Investigator: A. Selvapandiyan (Department of Biotechnology)
6. Assembly and release of paramyxovirus(es) from host cell Principal Investigator – Dr. Anuja Krishnan (Department of Science & Technology)

    

   Other missions of Department of Research is to advance educational research and to train the next generation of scholars to focus on specific areas of research for advancement of medical science as well as promotion of basic science research, for development of cutting-edge Science & Technology. Towards this end, a Summer Training Program was envisaged.

   Summer Training Program

   The department conducts a short – term summer training program (2-monthly and 6-monthly) for post-graduate students from different Universities. This program has been designed based on the existing areas of research strength in the hospital to enhance linkages between the SGRH researchers and outside organizations, both nationally and internationally.

   Currently, we are providing training on techniques associated with molecular biology (Real-time PCR, PCR, Spectrophotometer), Immunology (Flow cytomtery, ELISA, Western), handling eukaryotic culture (mammalian cell-lines, bacteria,/yeast cultures) that are related to in the fields of Oncology, Neurology, Transplantation and other related subjects. Application form is enclosed in the link. Please download the form and submit as informed.

   

   Short-Term Training Program - Format

   PhD Program

   Sir Ganga Ram Hospital conducts its PhD program in affiliation with Guru Gobind Singh Indraprastha University (GGSIPU) Delhi in the School of Medicine & Para Medical Health Sciences (USMPMHS). This University was established by Government of NCT of Delhi under the provisions of Guru Gobind Singh Indraprastha University Act, 1998 along with its Amendment in 1999.The University is recognized by University Grants Commission (UGC), India under section 12B of UGC Act. It is an affiliating and teaching University that aims to facilitate and promote studies, research and extension work in emerging areas of higher education with focus on professional education in the disciplines of engineering, technology, architecture, management, medicine, pharmacy, physiotherapy, nursing, education, law, journalism and mass communication, etc. It has been accredited A Grade" by NAAC during Feb - March 2007.

   The University provides the doctoral degree under various schools of Sciences:

   

   Sir Ganga Ram Hospital is affiliated to GGSIPU as an Approved Research Centre since June 2007.  Our program is designed to produce scholars who have the capability to enhance intellectual understanding of medical science theory and effectively transmit this knowledge for patient care.

   The PhD program is being coordinated by the Department of Research. Currently, 7 students from various departments such as Genetic Medicine, Medical Oncology etc are registered for the PhD program. The details of recognised supervisors, scholars enrolled and other information are as mentioned in the links herein.

   SGRH fosters fundamental creative discoveries and innovative research strategies to protect, improve human health and the same time promote the highest level of scientific integrity accountability and social responsibility in the conduct of biomedical research. Thereby,Department of Research is also engaged in an administrative effort to process and maintain the records of research projects undertaken at the hospital. All research project applications are submitted to the department for administrative vetting with respect to financial and legal matters and for keeping record as well as onward transmission for further processing.

   Processing of Clinical Applications

   Investigator-initiated projects (for extra-mural funding)

   In the normal course the above applications are simultaneously forwarded to the Ethics Committee, Finance and Legal departments for their respective clearance. However, in case the Principal Investigator (PI) wishes to seek advice of the Research Committee, the applications are first submitted to the said committee for scientific inputs. Once the application is amended according to the advice the Research Committee, it is forwarded for approval to the above mentioned committee/ department for clearance.

   Investigator-initiated projects (for intra-mural funding)

   Those investigator-initiated projects that require support from intra-mural resources of Sir Ganga Ram Hospital are first directed by the department to the Research Committee.  The latter may constitute a Project Review Sub-Committee of experts, if needed. Once the approval of the Research Committee is obtained, the applications are forwarded to the Ethics Committee for ethical clearance.  Once cleared, the applications are forwarded to the department for fund release. All research projects supported through intra-mural funding undergo periodic scrutiny by a Monitoring Committee (appointed by the Research Committee) for evaluation and progress.

   Trials sponsored by Pharmaceutical Companies 

   Applications sponsored by pharmaceutical companies are forwarded initially to the department for financial and legal vetting followed by clearance by the Ethics Committee.

   The Department of Research of Sir Ganga Ram Hospital is kept informed and involved at all times about the research projects being undertaken in the hospital.

   The procedure of submission of projects for Ethics/Legal/Finance is mentioned in the link below. Also attached is the form for submission of project proposals to Department of Research.

   1. Epigenomic characterization of triple negative breast cancer and its role in tumor micro-environmentPrincipal Investigator: Dr. Sangeeta ChoudhuryFunding Agency: Department of Biotechnology
   2. Towards the understanding of immunoregulatory and immunotolerant effect of immunosuppressive drugs in Living Donor Liver Transplant recipientsPrincipal Investigator: Dr. Sangeeta ChoudhuryFunding Agency: ICMR under "Grant-in-aid of DHR.
   3. Clinical Significance of Cancer Stem Cell Markers and Its Proteins in GlioblastomaPrincipal Investigator: - Dr. Dheeraj MohaniaFunding Agency: Indian Council of Medical Research
   4. Towards the understanding of molecular pathogenesis of Amyotrophic Lateral Sclerosis: a comprehensive profiling of the protein quality control machinery of peripheral monocytes Principal Investigator: Dr. Vibha TanejaFunding Agency: Indian Council of Medical Research
   5. Cytotoxic effects and amyloidogenic potential of disease-associated variants of transthyretin and screening of therapeutics for transthyretin amyloidosis in a humanized yeast modelPrincipal Investigator: Dr. Vibha TanejaFunding Agency: Department of Biotechnology
   6. Expression profile of angiogenesis-related genes in Pediatric Acute Lymphoblastic Leukemia Co-Investigator: Dr. Veronique Dinand
      • Chairman : Dr. D. S. Rana
      • Advisor : Prof. N. K. Ganguly
      • Coordinator : Dr. Sangeeta Choudhury
      • University School of Medicine & Para Medical Health Sciences
      • University School of Basic & Applied Sciences
      • University School of Biotechnology
      • University School of Environmental Sciences
      • University School of Chemical Technology
      • Details of candidates registered for Doctoral Program (2009-12)
      • Database of recognized PhD supervisors
      • Special elective course in research (directed study) - PhD program

      The Research Committee

      Role of Research Committee: To encourage and facilitate ethical and quality research that should be published in reputed journals. Good research will finally help in good patient care

      The Research Committee provides leadership and supervises all research activities to support the efforts of the institution in developing future research. The Research Committee is headed by Dr. D. S. Rana, Chairman, Board of Management, chaired by Prof. N. K. Ganguly, co-chaired by Prof. N. C. Nayak, Dr. Samiran Nundy, and vice-chaired byDr. I. C. Verma.

      Other members include:

      Key roles of research committee are:

      Research Development Program (RDP) initiated with the aim to provide financial support (a grant-in-aid) and thus encourage and augment research in our hospital. The committee invites proposals from investigators to start a pilot study that will lead to a major project development which will be funded by government funding agencies. RDP projects approved and sanctioned till date are mentioned in the link attachment herein.

      Future Plans

      Recent Publications (2009-2012)

      • Schematic representation of SOP for Clinical Trial
      • Schematic representation of SOP for Research Project
      • Form for submission of clinical trial and projects
      • Clinical Research (2011-12)
      • Clinical Research (2011-13)
        • Dr. K. C. Mahajan
        • Dr. L. M. Srivastava
        • Dr. Kusum Verma
        • Dr. Manorama Bhargava
        • Dr. Chand Wattal
        • Dr. Shyam Aggarwal
        • Dr. J. P. S. Sawhney
        • Dr. C. S. Agarwal
        • Dr. Anupam Sachdeva
        • Dr. R. K. Saran
        • Dr. M. Gourie Devi
        • Dr. D. Khullar
        • Interactive Consultant Program facilitating to carry out research and thereby accomplish scientifically.
        • Managing and executing the Research Development Program (Intramural grant).
        • Research projects that require intramural funding are initially forwarded to Research Committee. The latter also examines projects requiring extramural funding in case the Principal Investigator wishes scientificinputs/advice of the said committee. The Committee examines the scientific merits of the research projects and makes necessary suggestions for amending/modifying the research proposals if and when required.
        • Awarding the annual award for the “First Author of the Best – published Paper”.
        • Intramural funding (Research Development Program 2011-12)
        • Intramural funding (Research Development Program 2012-13)
        1. Expanding the Research facility with state-of-the-art analytical equipments (Confocal Microscope, Bioimager, HPLC, LC/MS/MS, Bioanalyzer, etc.) to facilitate in-depth research in the areas of Molecular and Cell Biology, Stem Cell Biology, Genomics and Proteomics, Experimental and Molecular Pathology, Cardiovascular Sciences, Neuroscience, Oncology, Virology, Immunology and other related subjects.
        2. Establishment of Stem Cell Facility

         

        Recent Publications (2009-2012)

        1. Jha P, Kumar R, Khera A, Bhattacharya M, Arora P, Gajalakshmi V, Bhatia P, Kam D, Bassani DG, Sullivan A, Suraweera W, McLaughlin C, Dhingra N, Nagelkerke N; Million Death Study Collaborators. HIV mortality and infection in India: estimates from nationally representative mortality survey of 1.1 million homes. BMJ. 2010; 340: c621
        2. Hajela N, Nair GB, Ganguly NK. Are probiotics a feasible intervention for prevention of diarrhoea in the developing world? Gut Pathog. 2010; 29:10.
        3. Gupta M, Kumar R, Deb AK, Bhattacharya SK, Bose A, John J, Balraj V, Ganguly NK, Kant L, Kapoor AN, Watt J, Shearer J, Santosham M; Hib study working group. Multi-center surveillance for pneumonia & meningitis among children (
        4. Kirtaniya BC, Chawla HS, Tiwari A, Ganguly NK, Sachdev V. Natural prevalence of antibody titers to Glucostltransferase of Streptococcus mutans in serum in high and low caries active children. J Indian Soc Pedod Prev Dent. 2010; 28: 91-94
        5. Sur D, Nair GB, Lopez AL, Clemens JD, Katoch VM, Ganguly NK. Oral cholera vaccines--a call for action. Indian J Med Res. 2010; 131:1-3
        6. Kumar M, Kumar A, Nagpal R, Mohania D, Behare P, Verma V, Kumar P, Poddar D, Aggarwal PK and Yadav H. Preventive attributes of probiotics in cancer: A review. International Journal of Food Science & Nutrition, 2010; 61: 473-496.
        7. Behare PV, Singh R, Tomar SK, Nagpal R, Kumar M, Mohania D. Effect of use of exopolysaccharide producing strains of streptococcus thermophilus on technological attributes of lassi. Journal of Dairy Science, 2010; 93: 2874-2879.
        8. Sur D, Ochiai RL, Bhattacharya SK, Ganguly NK, Ali M, Manna B, Dutta S, Donner A, Kanungo S, Park JK, Puri MK, Kim DR, Dutta D, Bhaduri B, Acosta CJ, Clemens JD. A cluster-randomized effectiveness trial of Vi typhoid vaccine in India. N Engl J Med. 2009; 361: 335-44.
        9. Sur D, Lopez AL, Kanungo S, Paisley A, Manna B, Ali M, Niyogi SK, Park JK, Sarkar B, Puri MK, Kim DR, Deen JL, Holmgren J, Carbis R, Rao R, Nguyen TV, Donner A, Ganguly NK, Nair GB, Bhattacharya SK, Clemens JD. Efficacy and safety of a modified killed-whole-cell oral cholera vaccine in India: an interim analysis of a cluster-randomised, double-blind, placebo-controlled trial. Lancet. 2009; 374: 1694-702
        10. Choudhury S, Kakkar V, Suman P, Chakrabarti K, Vrati S, Gupta SK. Gupta. Immunogenicity of zona pellucida glycoprotein-3 and spermatozoa YLP12 peptides presented on Johnson grass mosaic virus-like particles. Vaccine 2009; 27: 2948-2953
        11. Choudhury S, Ganguly A, Chakrabarti K, Sharma RK, Gupta SK. DNA vaccine encoding chimeric protein encompassing epitopes of human ZP3 and ZP4: Immunogenicity and characterization of antibodies. J Reprod. Immunol 2009; 79: 137-147.
        12. Kumar R, Vohra H, Chakraborty A, Sharma YP, Bandhopadhya S, Dhanda V, Sagar V, Sharma M, Shah B, Ganguly NK. Epidemiology of group A streptococcal pharyngitis & impetigo: a cross-sectional & follow up study in a rural community of northern India. Indian J Med Res. 2009; 130: 765-71
        13. Kirtaniya BC, Chawla HS, Tiwari A, Ganguly NK, Sachdev V. Natural prevalence of antibody titres to GTF of S. mutans in saliva in high and low caries active children. J Indian Soc Pedod Prev Dent. 2009; 27: 135-8.
        14. Kumar M, Mohania D, Poddar D, Behare PV, Nagpal R. A probiotic fermented milk prepared by mixed culture combination reduces pathogen shedding and alleviates disease signs in rats challenged with pathogens. International Journal of prebiotics and probiotic, 2009; 4: 211-218
        15. Kumar M, Nagpal R, Mohania D, Poddar D and Aggarwal PK. Genetically modified foods: present scenario and future prospects. Beverage & Food World 2009; 36: 38-40
        16. Kumar M, Behare PV, Mohania D, Arora S, Kaur A and Nagpal R. Health-promoting probiotic functional foods: potential and prospects. Agro FOOD Industry Hi-tech 2009; 20: 29-33
        17. Mohania D, Nagpal R, Kumar M, Bhardwaj A, Yadav M, Jain S, Marotta F, Singh V, Parkash O, Yadav H. Molecular approaches for identification and characterization of lactic acid bacteria. J Dig Dis. 2008; 9:190-198
        18. Ganguly NK. State of the globe: The immunological quest for an HIV/AIDS vaccine continues. J Global Infect Dis 2011; 3 (3): 209-210.
        19. Laxminarayan R, Ganguly NK. India’s vaccine deficit: why more than half of Indian children are not fully immunized, and what can-and should-be done. Health Affairs 2011; 30 (6): 1096-1103.
        20. Gupta SK, Gupta N, Suman P, Choudhury S, Prakash K, Gupta T, Sriraman R, Nagendrakumar SB, Srinivasan VA. Zona pellucida-based contraceptive vaccines for human and animal utility. J Reprod Immunol. 2011: 88(2):240-246
        21. Kent SJ, Cooper DA, Chhi Vun M, Shao Y, Zhang L, Ganguly N, Bela B, Tamashiro H, Ditangco R, Rerks-Ngarm S, Pitisuttithum P, Van Kinh N, Bernstein A, Osmanov S; AIDS Vaccine for Asia Network investigators and supporters. AIDS vaccine for Asia Network (AVAN): expanding the regional role in developing HIV vaccines. PLoS Med 2010; 7(9):e1000331.
        22. Hajela N, Nair GB, Ganguly NK. Are probiotics a feasible intervention for prevention of diarrhoea in the developing world? Gut Pathog. 2010; 2: 10
        23. Kirtaniya BC, Chawla HS, Tiwari A, Ganguly NK, Sachdev V. Natural prevalence of antibody titers to glucosyltransferase of Streptococcus mutans in serum in high and low caries active children. J Indian Soc Pedod Prev Dent. 2010; 28: 91-94
        24. Jha P, Kumar R, Khera A, Bhattacharya M, Arora P, Gajalakshmi V, Bhatia P, Kam D, Bassani DG, Sullivan A, Suraweera W, McLaughlin C, Dhingra N, Nagelkerke N; Million Death Study Collaborators. HIV mortality and infection in India: estimates from nationally representative mortality survey of 1.1 million homes. BMJ. 2010; 340:c621. doi: 10.1136/bmj.c621
        25. Sur D, Nair GB, Lopez AL, Clemens JD, Katoch VM, Ganguly NK. Oral cholera vaccines--a call for action. Indian J Med Res. 2010; 131: 1-3
        26. Rerks-Ngarm S, Pitisuttithum P, Ganguly N, Zhang L, Tamashiro H A, Cooper D, Chhi Vun M, Bela B, Ditangco R, Van Kinh N, Bernstein A, Osmanov S, Mathieson B, J. Kent S, Shao Y. Defining the objectives of the AIDS vaccine for Asia network: report of the WHO-UNAIDS/Global HIV Vaccine enterprise regional consultation on expanding AIDS vaccine research and development capacity in Asia. Curr Opin HIV AIDS 2010; 5: 435-452
        27. Gupta M, Kumar R, Deb AK, Bhattacharya SK, Bose A, John J, Balraj V, Ganguly NK, Kant L, Kapoor AN, Watt J, Shearer J, Santosham M; Hib study working group. Multi-center surveillance for pneumonia & meningitis among children.
        28. Kalra M, Dinand V, Choudhury S, Radhakrishnan N, Prakash A, Kharya G, Yadav SP, Sachdeva A. Serum vascular endothelial growth factor (VEGF) levels during induction therapy in pediatric acute lymphoblastic leukemia. Ped Blood Cancer 2010; 55: 851.
        29. Behare PV, Singh R, Tomar SK, Nagpal R, Kumar M, Mohania D. 2010. Effect of exopolysaccharide-producing strains of Streptococcus thermophilus on technological attributes of fat-free lassi. J Dairy Sci. 2010; 93: 2874-2879.
        30. Kumar M, Kumar A, Nagpal R, Mohania D, Behare P, Verma V, Kumar P, Poddar D, Aggarwal PK, Henry CJ, Jain S, Yadav H. Cancer-preventing attributes of probiotics: an update. Int J Food Sci Nutr. 2010; 61: 473-496.
        31. Menon S, Jain S, Nagpal R, Kumar M, Mohania D, Yadav D, Marotta F, Yadav M and Yadav H. “Immunomodulatory potential of conjugated linolenic acid in Dietary Componants and Immune function”. Series: Nutrition and Health, Watson, Ronald Ross; Zibadi, Sherma; Preedy, Victor, R. (Eds.), Ist Edition, 2010 Humana Press (Springer).
        32. Bharati K, Ganguly NK. Does India need an indigenous HPV vaccine and why? J Public Health Policy 2013; Feb 28. doi: 10.1057/jphp.2013.4.
        33. Bharati K, Ganguly NK. Tackling the malaria problem in the South-East Asia Region: Need for a change in policy? Indian J Med Res 2013; Jan; 137(1):36-47.
        34. Ganguly NK, Sen Gupta S. A world without vaccines. Seminar 631: Shot in the arm: A symposium on the future of immunization, vaccination and childhood disease. March 2012; 59-62.
        35. Hajela N, Nair GB, Abraham P, Ganguly NK. Health impact of probiotics – vision and opportunities. Gut Pathogens 2012; 4: 1.
        36. Lagrange PH, Thangaraj SK, Dayal R, Despande A, Ganguly NK, Girardi E, Joshi B, Katoch K, Katoch VM, Kumar M, Lakshmi V, Leportier M, Longuet C, Malladi SV, Mukerjee D, Nair D, Raja A, Raman B, Rodrigues C, Sharma P, Singh A, Singh S, Sodha A, Kabeer BS, Vernet G, Goletti D. A toolbox for tuberculosis diagnosis: an Indian multicentric study (2006-2008): microbiological results. PLoS One. 2012; 7(8):e43739. doi: 10.1371/journal.pone.0043739.
        37. Dinand V, Kalra M, Choudhury S, Yadav SP, Sachdeva A. Serum vascular endothelial growth factor-a levels during therapy and at relapse in pediatric acute lymphoblastic leukemia. Ped Blood Cancer 2012; 59(6):1031
        38. Verma M, Sharma A, Naidu S, Bhadra AK, Kukreti R, Taneja V. Curcumin prevents formation of polyglutamine aggregates by inhibiting Vps36, a component of the ESCRT-II complex. PLoS One. 2012; 7(8):e42923.
        39. Dinand V, Yadav SP, Bellanné-Chantelot C, Jain S, Bhargava M, Sachdeva A. Hepatic hemangioendothelioma in an infant with severe congenital neutropenia. J Pediatr Hematol Oncol 2012; 34(4):298-300.
        40. Selvapandiyan A, Dey R., Gannavaram S., Lakhal-Naouar I., Duncan R., Salotra P. and Nakhasi H.L. Immunity to Visceral Leishmaniasis using Genetically Defined Live Attenuated Parasites. J. Trop Med. 2012; 1-12.
        41. Mohania D, Jauhri M., Aggarwal S., Kansal, V.K., Ganguly NK, Choudhury S, Mohania S, Jain K. Immuno-modulatory Potential of Probiotics. Microbes in the Service of Mankind: Tiny Bugs with Huge Impact". I.K. International Publishers, New Delhi. (In press)
        42. Nagpal R., Behare P. V., Kumar M., Mohania D., Yadav M., Jain S., Menon S., Parkash O., Marotta F., Minelli E., Henry C. J.K. and Yadav H. Milk, Milk Products, and Disease Free Health: An Updated Overview, Critical Reviews in Food Science and Nutrition, 2012: 52:4, 321-333.
        43. Krishnan A, Miller EH, Herbert AS, Melinda Ng, Ndungo E, Whelan SP, Dye JM, Chandran K. Niemann-Pick C1 (NPC1)/NPC1-like1 chimeras define sequences critical for NPC1’s function as a filovirus entry receptor. Viruses 2012: 4: 2471-2484,
        44. Miller EH, Obernosterer G, Raaben M, Herbert AS, Deffieu MS, Krishnan A, Ndungo E, Sandesara RG, Carette JE, Kuehne AI, Ruthel G, Pfeffer SR, Dye JM, Whelan SP, Brummelkamp TR, Chandran K. Ebola virus entry requires the host-programmed recognition of an intracellular receptor. EMBO J 2012: 31: 1947-1960.
        45. Selvapandiyan A, Kumar P, Salisbury J, Wang CC, Nakhasi HL. Centrins 2 and 3 involved in organelle segregation and cytokinesis in Trypanosoma brucei. PLOS One 2012; 7(9) e45288.
        46. Dey R, Dagur Pr K, Selvapandiyan A, McCoy JP, Salotra P, Duncan R, Nakhasi HL. Live Attenuated Leishmania donovani p27 Gene Knockout Parasites Are Non-pathogenic and Elicit Long Term Protective Immunity in BALB/c Mice. J. Immunol 2012 (in press)
        47. Dinand V, Bakhshi S, Jain S, Dhawan S, Yadav SP, Sachdeva A. Clinicopathological Conference: A 9-y-old Girl with Transient Chest Pain. Indian J Pediatr 2013. DOI 10.1007/s12098-012-0942-2
        48. Radhakrishnan N, Dinand V, Rao S, Gupta P, Toteja GS, Kalra M, Yadav SP, Sachdeva A. Antioxidant Levels at Diagnosis in Childhood Acute Lymphoblastic Leukemia. Indian J Pediatr 2012 Nov 28. [Epub ahead of print].
        49. Kalra M, Dinand V, Choudhury S, Sachdeva A, Yadav SP. Serum vascular endothelial growth factor-A levels during induction therapy in children with acute lymphoblastic leukemia. Indian Pediatr 2012 (accepted for publication)
        50. Dinand V. And what about pediatric neonatal palliative care? BMJ 2012. http://www.bmj.com/content/345/bmj.e7319/rr/614754
        51. Prakash A, Dinand V, Yadav SP, Sachdeva A. Hodgkin Lymphoma presenting with Multifocal Osseous Lesions in a Child. Pediatr Hematol Oncol 2012; 29(5):424-7