Research at SGRH
Sir Ganga Ram Hospital (SGRH) believes research to be an integral aspect of modern day medicine that allows the clinician to scientifically test assumptions, recognize uncertainties, widen perspective, resolve dilemmas and understanding divergent options and explore strategic questions. The existing facilities of teaching and research at SGRH together with a very large pool of patients makes for an ideal environment to evolve SGRH into an academic institution with a strong research base wherein the ultimate beneficiary is the patient.
A network of academically inclined clinicians of the Hospital and staff of the Clinical and Laboratory Facilities is available so that ideas generated in the clinics can be tested in a clinical research setting. Such a network will also help to develop discussion groups leading to generation of new ideas and discoveries in the laboratory, which can then be put to clinical testing in patients.
Department of Research, a Core Research Facility
Department of Research is a central facility with state-of-the-art equipments to support clinical research as well as promote translation research. The aim of the department is to promote laboratory-based investigation in multi-disciplinary areas, assist clinicians in pursuing their interest in research and provide technical and scientific manpower through collaborative projects. This is to facilitate ‘bench to bed’ side medicine and conduct innovative research to generate new knowledge in biology and medicine. Thus, as a central research department, it is responsible for bridging the various departments of the hospital to promote the highest level of scientific integrity, public accountability and social responsibility in the conduct of science. In realizing these goals, the department provides leadership and direction to programs designed ultimately to improve the health-care system.
Toward this end, the ‘missionof the Department of Research is to foster fundamental creative discoveries and innovative research strategies, protect and improve human health and, at the same time, to promote the highest level of scientific integrity, accountability, and social responsibility in the conduct of biomedical research.
The academic staff and post-graduate students of the department, conducts a wide range of researches and studies, particularly in the fields of oncology, immunology and molecular & cell biology. In addition, the department manages clinical / non-clinical studied by supporting every phase of preclinical / clinical development, according to NABH / ISO standard. Here are mentioned a few of the departments (as depicted in the sketch below) that are actively involved in various research activities along with the Department of Research. Presently, our department has established protocols to carry-out various molecular biological associated researches
A. Clinical Departments
B. Investigative Departments
KEY RESEARCH GROUPS
Academics at Sir Ganga Ram Hospital
SGRH has been recognized by National Board of Examinations as a teaching hospital to impart teaching and training of Diplomate of National Board of Examinations for Broad / Super-specialty degrees and Post-doctoral Fellowships in sub-specialties. The Hospital has been accorded the status of an Approved Research Center to undertake Post-Graduate students who can pursue higher studies to obtain a PhD degree in medical science subjects (details are mentioned below) by Guru Gobind Singh Indraprastha University (GGSIPU)
We the Team.....
Left to Right : (Standing) Dr Vibha Taneja, Dr Anuja Krishnan, Dr Selvapandiyan, Dr. NK Ganguly, Dr Sangeeta Choudhury,Dr. Dheeraj Mohania,Dr. Veronique Dinand, Ms Parul Chug (Sitting) Mr Chitrak Gupta, Mr Pramod Sahoo, Mr Swaroop Singh
The Department is advised by Prof. N. K. Ganguly, assisted by the Assoc Prof and Consultant, Dr. Sangeeta Choudhury and other faculty members Drs. Veronique Dinand, Vibha Taneja, Dheeraj Mohania and our Honorary Scientists Dr Selvapandiyan. Other team members are Ms Kriti Jain (Junior Scientist), Ms Parul Chug (Statistician) and Mr Chitrak Gupta (Secretary to Chairman), Mr Pramod Sahoo (Jr. Executive Mr Radhyesh Notiyal (Assistant Manager). This team not only manages the functioning of the department but also provides invaluable support to Sir Ganga Ram Hospital in its research endeavors. Sir Ganga Ram Hospital is the only private hospital comprising of an independent state-of-art research facility.
The Department of Research in Sir Ganga Ram Hospital (SGRH) has a three part mission: teaching, research and supporting all scientific undertakings
The mission is to:
The Department of Research since its establishment in 2007 with a maximum staff of six membersalong with 6-7 active researchers networking across the hospital, undertook the task of evolving as a dedicated facility with state-of-the-art equipments. One of its major responsibilities is to bridge various departments to foster laboratory-based investigation in multi-disciplinary areas to support clinical research by developing intra-/inter-departmental collaborative research projects.
The academic faculty of the department is involved in clinical and basic research in different aspects of medicine. Mainly, research activity is conducted by a core research group (Department of Research) which pursues novel ideas at a fundamental level that have the potential to evolve into practical diagnostics or therapeutic practices. The infrastructure of the department is well established with this dedicated team of researchers who provides support to various departments to conduct their research activities. One of the main aims is to ultimately translate research findings into health care services and strategies, for use by clinicians and evaluate innovative studies to improve the effectiveness and efficiency in providing evidence-based practice.
Intramural funded (Research Development Program)Projects (2016-2017):
|Sl. No.||Project Title/ Account Code||Investigator @ Dept. of Research||Collaboration (SGRH Department)|
|1||Use of Peripheral T-Regulatory/Dendritic cells as a risk assessment test to Identify abnormal development of pregnancy leading to miscarriages||Dr. Sangeeta Choudhury,Ms Kriti Jain||Obstetrics & Gynaecology|
|2||Exploring the genetic association of ABC transporters with acute lymphoblastic leukemia||Dr. Veronique Dinand||Pediatric Hemato- Oncology and BMT Unit|
|3||Association of markers of ovarian reserve with lipid profile in Indian Premenopausal women||Dr. Sangeeta Choudhury||Obstetrics & Gynaecology|
|4||Use of Neutrophil Biomarkers to diagnose Neonatal Sepsis and predict septic shock||Dr. Sangeeta Choudhury||Neonatology|
|5||Nutritional biomarkers in the progression of mild cognitive impairment and early dementia||Dr. Sangeeta Choudhury||Biochemistry and Neurology|
|6||Exploring the potential of Mesenchymal Stem Cells to target the pancreatic Cancer Stem Cells||Dr. Sangeeta Choudhury,Ms Kriti Jain||Surgical gastroenterology & Liver Transplantation; Gastroenterology & Pancreatico Biliary Sciences|
|7||Evaluation for underlying genetic predisposition in children with life threatening bacterial and viral infections||Dr. Veronique Dinand||Pediatric Hematology Oncology & BMT Unit & Pediatric Intensive Care|
|8||Reprogramming of Motor Neurons from Peripheral Blood Mononuclear cells to develop a functional model for sporadic ALS||Dr. Vibha Taneja||Neurophysiology & Neurology|
|9||Establishing and validation of a motor neuron cell line model for a familial L84F SOD1 mutation||Dr. Vibha Taneja||Neurophysiology|
|10||Optimization of collection, isolation, expansion, characterization and cryopreservation of bone-marrow derived mesenchymal stem cells||Dr. D.S. Rana, Dr. Vibha Taneja, Kumar Digvijay, Dr. D. Mohania, Ms Kriti Jain||Nephrology|
|11||Correlation of biomolecular levels of Progranulin and its association with NF-kB/β-catenin signaling pathway in the patients with intervertebral lumbar disc prolapse with the preoperative MRI and clinical outcomes after microlumbar discectomy||Dr. D Mohania||Orthospine|
|12||To explore the crosstalk of SIRT-1 with IL23/Th17/STAT3/Wnt signaling pathway and their clinical correlation with disease outcome of newly diagnosed patients with Rheumatoid arthritis||Dr. D Mohania||Rheumatology|
|13||To explore the impact of packed red blood cell (PRBCs) on transfusion related immunomodulation (TRIM) in critically ill ICU admitted patients||Dr. D Mohania, Ms Kriti Jain||Transfusion Medicine & Critical Care Medicine|
|14||Towards understanding the mechanisms of immunomodulation, gut maturation and their correlation with clinical outcome in very low birth weight (VLBW) infants||Dr. D Mohania||Neonatology|
Project Proposals submitted for external funding (2013)
Other missions of Department of Research is to advance educational research and to train the next generation of scholars to focus on specific areas of research for advancement of medical science as well as promotion of basic science research, for development of cutting-edge Science & Technology. Towards this end, a Summer Training Program was envisaged.
Summer Training Program
The department conducts a short – term summer training program (2-monthly and 6-monthly) for post-graduate students from different Universities. This program has been designed based on the existing areas of research strength in the hospital to enhance linkages between the SGRH researchers and outside organizations, both nationally and internationally.
Currently, we are providing training on techniques associated with molecular biology (Real-time PCR, PCR, Spectrophotometer), Immunology (Flow cytomtery, ELISA, Western), handling eukaryotic culture (mammalian cell-lines, bacteria,/yeast cultures) that are related to in the fields of Oncology, Neurology, Transplantation and other related subjects. Application form is enclosed in the link. Please download the form and submit as informed.
Short-Term Training Program - Format
Sir Ganga Ram Hospital conducts its PhD program in affiliation with Guru Gobind Singh Indraprastha University (GGSIPU) Delhi in the School of Medicine & Para Medical Health Sciences (USMPMHS). This University was established by Government of NCT of Delhi under the provisions of Guru Gobind Singh Indraprastha University Act, 1998 along with its Amendment in 1999.The University is recognized by University Grants Commission (UGC), India under section 12B of UGC Act. It is an affiliating and teaching University that aims to facilitate and promote studies, research and extension work in emerging areas of higher education with focus on professional education in the disciplines of engineering, technology, architecture, management, medicine, pharmacy, physiotherapy, nursing, education, law, journalism and mass communication, etc. It has been accredited A Grade" by NAAC during Feb - March 2007.
The University provides the doctoral degree under various schools of Sciences:
Sir Ganga Ram Hospital is affiliated to GGSIPU as an Approved Research Centre since June 2007. Our program is designed to produce scholars who have the capability to enhance intellectual understanding of medical science theory and effectively transmit this knowledge for patient care.
The PhD program is being coordinated by the Department of Research. Currently, 7 students from various departments such as Genetic Medicine, Medical Oncology etc are registered for the PhD program. The details of recognised supervisors, scholars enrolled and other information are as mentioned in the links herein.
SGRH fosters fundamental creative discoveries and innovative research strategies to protect, improve human health and the same time promote the highest level of scientific integrity accountability and social responsibility in the conduct of biomedical research. Thereby,Department of Research is also engaged in an administrative effort to process and maintain the records of research projects undertaken at the hospital. All research project applications are submitted to the department for administrative vetting with respect to financial and legal matters and for keeping record as well as onward transmission for further processing.
Processing of Clinical Applications
Investigator-initiated projects (for extra-mural funding)
In the normal course the above applications are simultaneously forwarded to the Ethics Committee, Finance and Legal departments for their respective clearance. However, in case the Principal Investigator (PI) wishes to seek advice of the Research Committee, the applications are first submitted to the said committee for scientific inputs. Once the application is amended according to the advice the Research Committee, it is forwarded for approval to the above mentioned committee/ department for clearance.
Investigator-initiated projects (for intra-mural funding)
Those investigator-initiated projects that require support from intra-mural resources of Sir Ganga Ram Hospital are first directed by the department to the Research Committee. The latter may constitute a Project Review Sub-Committee of experts, if needed. Once the approval of the Research Committee is obtained, the applications are forwarded to the Ethics Committee for ethical clearance. Once cleared, the applications are forwarded to the department for fund release. All research projects supported through intra-mural funding undergo periodic scrutiny by a Monitoring Committee (appointed by the Research Committee) for evaluation and progress.
Trials sponsored by Pharmaceutical Companies
Applications sponsored by pharmaceutical companies are forwarded initially to the department for financial and legal vetting followed by clearance by the Ethics Committee.
The Department of Research of Sir Ganga Ram Hospital is kept informed and involved at all times about the research projects being undertaken in the hospital.
The procedure of submission of projects for Ethics/Legal/Finance is mentioned in the link below. Also attached is the form for submission of project proposals to Department of Research.
The Research Committee
Role of Research Committee: To encourage and facilitate ethical and quality research that should be published in reputed journals. Good research will finally help in good patient care
The Research Committee provides leadership and supervises all research activities to support the efforts of the institution in developing future research. The Research Committee is headed by Dr. D. S. Rana, Chairman, Board of Management, chaired by Prof. N. K. Ganguly, co-chaired by Prof. N. C. Nayak, Dr. Samiran Nundy, and vice-chaired byDr. I. C. Verma.
Other members include:
Key roles of research committee are:
Research Development Program (RDP) initiated with the aim to provide financial support (a grant-in-aid) and thus encourage and augment research in our hospital. The committee invites proposals from investigators to start a pilot study that will lead to a major project development which will be funded by government funding agencies. RDP projects approved and sanctioned till date are mentioned in the link attachment herein.
Recent Publications (2009-2012)
Recent Publications (2009-2012)